The Peptide Evidence Index

Best peptides, ranked by evidence

Here best means most backed by human trials, not most sold. Of 2,544 studies indexed across 28 peptides, only 16% is human evidence — 33% is animal or in-vitro. This page ranks every peptide by that share.

Studies indexed
2,544
Human evidence
16%
Preclinical
33%
Peptides ranked
28

The evidence, all peptides combined

  • Human RCT 4%
  • Human trial 13%
  • Review 31%
  • Animal 19%
  • In-vitro 13%
  • Unknown 19%

The ranking

Sorted by human-evidence share, strongest first. Search demand shown for context.

# Peptide Searches/mo Human Preclinical Top grade
1 Thymosin Alpha-1 1,000 51% 11% Human RCT
2 Tirzepatide 716,000 37% 6% Human RCT
3 Survodutide 5,800 31% 24% Human RCT
4 Tesamorelin 58,000 28% 15% Human RCT
5 Semaglutide 536,000 25% 13% Human RCT
6 Melanotan 1 150 23% 16% Human RCT
7 Ibutamoren 17,000 18% 32% Human RCT
8 Pinealon 4,700 18% 66% Animal
9 Cagrilintide 21,000 16% 32% Human RCT
10 AOD-9604 3,500 15% 35% Human trial
11 Kisspeptin 3,700 14% 59% Human trial
12 MOTS-c 20,000 13% 35% Preclinical
13 Retatrutide 314,000 12% 27% Human RCT
14 PT-141 6,100 11% 13% Human RCT
15 Ipamorelin high demand, low evidence 30,000 9% 36% Preclinical
16 Selank 4,300 9% 59% Preclinical
17 GHK-Cu high demand, low evidence 13,000 7% 56% Preclinical
18 Gonadorelin 5,900 7% 55% Human trial
19 Epitalon 3,300 7% 54% Preclinical
20 Semax high demand, low evidence 10,000 4% 66% Preclinical
21 CJC-1295 9,500 4% 35% Preclinical
22 Humanin 600 4% 36% Preclinical
23 Sermorelin high demand, low evidence 117,000 3% 20% Human trial
24 BPC-157 high demand, low evidence 47,000 2% 38% Animal
25 DSIP 5,000 2% 55% Preclinical
26 TB-500 5,800 0% 53% Preclinical
27 5-Amino-1MQ 5,000 0% 100% Animal
28 KPV 1,700 0% 65% Preclinical

By goal

Same ranking, filtered to what people actually search for: best peptides for muscle growth , best peptides for weight loss , best peptides for healing .

The hype gap

5 peptides draw 217,000 searches a month between them, yet each has under 10% human evidence in the indexed corpus. The most searched is Sermorelin (3% human) , BPC-157 (2% human) , Ipamorelin (9% human) . Popularity is not evidence — see how we grade evidence for what each level means.

How to read this

Each share is computed from the studies this site has indexed for a molecule, graded by their strongest design (human RCT down to in-vitro). Study-level grading is automated, so the per-molecule figures reflect the indexed corpus — weighted toward recent literature — not a molecule's entire history: an older approved analog can show a low human share if its recent indexed studies are reviews. The combined 16% human figure is robust. Full method on our methodology page. Research information only, not medical advice.

Frequently asked questions

What are the best peptides by evidence?
Ranked by human evidence, the peptides with the strongest human-trial backing are approved drugs such as Thymosin Alpha-1 and Tirzepatide. Across 28 peptides and 2544 indexed studies, only 16% of the evidence is human.
Are peptides safe?
Safety in humans is not established for most research peptides: 33% of the indexed evidence is preclinical (animal or in-vitro) and only 16% is human. This is research information, not medical advice.
Do peptides work?
It depends on the molecule. A few have human randomized-trial evidence; many popular research peptides are supported mainly by animal and in-vitro studies. The ranking above shows the human-evidence share for each.

Search demand captured · evidence corpus refreshed weekly · sourced to primary documents