Best peptides for weight loss
Research information only, not medical advice. The peptides with genuine weight-loss evidence are the GLP-based drugs. Ranked below by human evidence — the approved and late-stage ones lead by a wide margin over the research peptides also marketed for fat loss.
| # | Peptide | Searches/mo | Human | Preclinical | Top grade |
|---|---|---|---|---|---|
| 1 | Survodutide | 5,800 | 31% | 23% | Human RCT |
| 2 | Tirzepatide | 716,000 | 27% | 7% | Human RCT |
| 3 | Semaglutide | 536,000 | 21% | 14% | Human RCT |
| 4 | Cagrilintide | 21,000 | 14% | 29% | Human RCT |
| 5 | AOD-9604 | 3,500 | 14% | 37% | Human trial |
| 6 | MOTS-c high demand, low evidence | 20,000 | 9% | 27% | Preclinical |
| 7 | Retatrutide high demand, low evidence | 314,000 | 8% | 18% | Human RCT |
Ranked by the share of indexed studies that is human, Survodutide leads the peptides studied for weight loss. For the full picture across every peptide, see the Peptide Evidence Index, or open a molecule to read its trials and regulatory status. How each level is assigned is on our methodology page.
Frequently asked questions
- What is the best peptide for weight loss?
- Ranked by human evidence, Survodutide has the strongest human backing of the peptides studied for weight loss (31% of its indexed studies are human). Most others in this list rest mainly on animal or in-vitro work.
- Do peptides work for weight loss?
- For most of these peptides the human evidence is limited — the table shows the human-evidence share for each. This is research information, not medical advice.
Search demand captured · evidence corpus refreshed weekly · sourced to primary documents