Research information only, not medical advice. Research peptide, not approved for human use anywhere. Up for an FDA advisory committee vote on July 23, 2026 (evaluated indication: Wound healing). Removed from the FDA 'do not compound' list in April 2026 but not yet compoundable.
TB-500 at a glance
As of June 2026 the human evidence is limited; most data is preclinical. See the indexed studies below, graded by evidence level.
All seven peptides on the agenda are covered in the July 2026 FDA peptide meeting. See also BPC-157 vs TB-500.
Evidence profile
100 studies- Human trial 9 · 9%
- Review 23 · 23%
- Animal 12 · 12%
- In-vitro 37 · 37%
- Unknown 19 · 19%
The longer the green, the stronger the human evidence. For most research peptides the bar is dominated by animal and in-vitro work, which is a signal to read every claim carefully.
Regulatory status
- 2026-04-22 US-FDA
Removed from the FDA 503A 'do not compound' Category 2 (nominations withdrawn) — still not eligible for compounding. source
- 2026-07-23 US-FDA · upcoming
FDA Pharmacy Compounding Advisory Committee vote (evaluated indication: Wound healing); docket FDA-2025-N-6895. source
Clinical trials
-
TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD
Indexed research
Sorted by evidence level, strongest first.
- Human trial 2025Effects of combined application of pig manure composts prepared using different fermentation methods with chemical fertilizer on winter wheat yield, light-thermal physiology, and soil biological characteristics
This field study in China found that combining acid-regulated pig manure compost with chemical fertilizer at a 25:75 ratio improved winter wheat yield, nutrient uptake, and soil properties.
- Human trial 2025The Prognostic Significance of TMSB4X in Glioma Patients
This study analyzes TMSB4X expression in glioma patients using TCGA and CGGA datasets, finding it as an independent prognostic indicator.
- Human trial 2025Association Between Thymosin β4 and Coronary Arterial Lesions in Children with Kawasaki Disease
This study measured serum thymosin β4 levels in children with Kawasaki disease and found lower levels in patients, especially those with coronary artery lesions, suggesting a role in inflammation and disease progression.
- Human trial 2026Active tuberculosis case finding using portable radiography reveals high undetected burden in rural Himachal Pradesh
This implementation study used portable radiography for active tuberculosis case finding in rural Himachal Pradesh, revealing a high undetected burden and identifying structural barriers to case detection.
- Human trial 2026Enhanced response obtainability with chirp stimulus in bone-conducted mVEMPs
This study compares chirp and tone burst stimuli in bone-conducted masseter vestibular-evoked myogenic potentials, finding chirp stimuli improve response rates and signal quality.
- Human trial 2026Analisis Window Width Dan Window Level Pada Window Lung Pemeriksaan CT-Scan Thorax Dengan Kasus TB Paru
This study compares different window width and window level settings on thoracic CT scans to determine optimal image quality for visualizing pulmonary tuberculosis lesions.
- Human trial 2025Multimodal assessment of chronic myelomonocytic leukemia with extramedullary involvement reveals RAS pathway activation, adverse outcomes and epithelial-mesenchymal transition
This study of 574 CMML patients finds that extramedullary disease is associated with RAS pathway mutations, adverse outcomes, and epithelial-mesenchymal transition.
- Human trial 2025Data Sheet 1_Effects of combined application of pig manure composts prepared using different fermentation methods with chemical fertilizer on winter wheat yield, light-thermal physiology, and soil biological characteristics.docx
This field study examines the effects of combining pig manure composts from different fermentation methods with chemical fertilizers on winter wheat yield and soil properties.
- Human trial 2025A – 75 Early Math Competency and High School Math Grades: Investigating the Moderating Effects of Critical Thinking Skills and Math Self-Efficacy in Chinese Adolescents
This study examines how critical thinking skills and math self-efficacy moderate the link between early math competency and high school math grades in Chinese adolescents.
- Review 2026Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
+ 90 more studies indexed for TB-500.
Frequently asked questions
- Is TB-500 approved for human use?
- Research peptide, not approved for human use anywhere. Up for an FDA advisory committee vote on July 23, 2026 (evaluated indication: Wound healing). Removed from the FDA 'do not compound' list in April 2026 but not yet compoundable.
- What does the research on TB-500 show?
- As of June 2026 the human evidence is limited; most data is preclinical. See the indexed studies below, graded by evidence level.