The Peptide Evidence Index

Best peptides, ranked by evidence

Here best means most backed by human trials, not most sold. Of 4,035 studies indexed across 28 peptides, only 14% is human evidence — 29% is animal or in-vitro. This page ranks every peptide by that share.

Studies indexed
4,035
Human evidence
14%
Preclinical
29%
Peptides ranked
28

The evidence, all peptides combined

  • Human RCT 3%
  • Human trial 11%
  • Review 31%
  • Animal 17%
  • In-vitro 12%
  • Unknown 26%

The ranking

Sorted by human-evidence share, strongest first. Search demand shown for context.

# Peptide Searches/mo Human Preclinical Top grade
1 Thymosin Alpha-1 1,000 42% 25% Human RCT
2 Survodutide 5,800 31% 23% Human RCT
3 Tirzepatide 716,000 27% 7% Human RCT
4 Tesamorelin 58,000 25% 14% Human RCT
5 Semaglutide 536,000 21% 14% Human RCT
6 Melanotan 1 150 21% 16% Human RCT
7 Pinealon 4,700 17% 63% Animal
8 Ibutamoren 17,000 16% 32% Human RCT
9 Cagrilintide 21,000 14% 29% Human RCT
10 AOD-9604 3,500 14% 37% Human trial
11 Kisspeptin 3,700 12% 59% Human trial
12 PT-141 6,100 11% 14% Human RCT
13 MOTS-c high demand, low evidence 20,000 9% 27% Preclinical
14 Retatrutide high demand, low evidence 314,000 8% 18% Human RCT
15 Ipamorelin high demand, low evidence 30,000 8% 34% Preclinical
16 Selank 4,300 8% 61% Preclinical
17 GHK-Cu high demand, low evidence 13,000 7% 49% Preclinical
18 Epitalon 3,300 6% 51% Preclinical
19 Semax high demand, low evidence 10,000 5% 62% Preclinical
20 Gonadorelin 5,900 5% 51% Human trial
21 CJC-1295 9,500 4% 33% Preclinical
22 Sermorelin high demand, low evidence 117,000 3% 20% Human trial
23 BPC-157 high demand, low evidence 47,000 3% 33% Animal
24 DSIP 5,000 2% 52% Preclinical
25 KPV 1,700 2% 53% Preclinical
26 Humanin 600 2% 30% Preclinical
27 TB-500 5,800 1% 44% Preclinical
28 5-Amino-1MQ 5,000 0% 100% Animal

By goal

Same ranking, filtered to what people actually search for: best peptides for muscle growth , best peptides for weight loss , best peptides for healing .

The hype gap

7 peptides draw 551,000 searches a month between them, yet each has under 10% human evidence in the indexed corpus. The most searched is Retatrutide (8% human) , Sermorelin (3% human) , BPC-157 (3% human) . Popularity is not evidence — see how we grade evidence for what each level means.

How to read this

Each share is computed from the studies this site has indexed for a molecule, graded by their strongest design (human RCT down to in-vitro). Study-level grading is automated, so the per-molecule figures reflect the indexed corpus — weighted toward recent literature — not a molecule's entire history: an older approved analog can show a low human share if its recent indexed studies are reviews. The combined 14% human figure is robust. Full method on our methodology page. Research information only, not medical advice.

Frequently asked questions

What are the best peptides by evidence?
Ranked by human evidence, the peptides with the strongest human-trial backing are approved drugs such as Thymosin Alpha-1 and Survodutide. Across 28 peptides and 4035 indexed studies, only 14% of the evidence is human.
Are peptides safe?
Safety in humans is not established for most research peptides: 29% of the indexed evidence is preclinical (animal or in-vitro) and only 14% is human. This is research information, not medical advice.
Do peptides work?
It depends on the molecule. A few have human randomized-trial evidence; many popular research peptides are supported mainly by animal and in-vitro studies. The ranking above shows the human-evidence share for each.

Search demand captured · evidence corpus refreshed weekly · sourced to primary documents