Research information only, not medical advice. In the STEP 1 trial, once-weekly semaglutide 2.4 mg produced a mean body-weight reduction of about 15% at 68 weeks, versus about 2% with placebo. Results outside trials vary.
The weight changes with semaglutide come from large randomised trials, not personal transformations. In the STEP 1 obesity trial (Wilding et al., NEJM 2021), once-weekly semaglutide 2.4 mg — the weight-management dose — produced a mean body-weight reduction of 14.9% at 68 weeks, versus 2.4% with placebo. This is trial data for an approved drug at its approved dose, reported as evidence rather than medical advice.
For the full evidence base, clinical trials, and regulatory status, see the Semaglutide research overview . Related: semaglutide side effects , semaglutide dosage .
Sources
Frequently asked questions
- How much weight do you lose on semaglutide?
- In the STEP 1 trial, semaglutide 2.4 mg once weekly produced about 15% mean body-weight reduction at 68 weeks. Individual results outside trials vary.
- How long does semaglutide take to work?
- STEP 1 measured its weight-loss result at 68 weeks, with the dose increased gradually over the first weeks of treatment.
Updated · sourced to primary documents